PDBe 1xv9

X-ray diffraction
2.7Å resolution

crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione.

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Nuclear receptor subfamily 1 group I member 3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 246 amino acids
Theoretical weight: 28.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14994 (Residues: 103-352; Coverage: 70%)
  • Best match: Q14994-5 (Residues: 74-319)
Gene names: CAR, NR1I3
Structure domains: Retinoid X Receptor
Retinoic acid receptor RXR-alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 236 amino acids
Theoretical weight: 26.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 227-462; Coverage: 51%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 1 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 13 amino acids
Theoretical weight: 1.63 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 685-697; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P3221
Unit cell:
a: 128.442Å b: 128.442Å c: 214.53Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.181 0.181 0.239
Expression systems:
  • Escherichia coli
  • Not provided