Function and Biology

Structure of small GTPase human Rheb in complex with GTP

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: regulation of type B pancreatic cell development
Cellular component: extracellular exosome

Sequence family

Pfam Protein family (Pfam)
PF00071
Domain description: Ras family
Occurring in:
  1. GTP-binding protein Rheb
The deposited structure of PDB entry 1xts contains 1 copy of Pfam domain PF00071 (Ras family) in GTP-binding protein Rheb. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001806
Domain description: Small GTPase
Occurring in:
  1. GTP-binding protein Rheb
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. GTP-binding protein Rheb
IPR020849
Domain description: Small GTPase, Ras-type
Occurring in:
  1. GTP-binding protein Rheb
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. GTP-binding protein Rheb

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. GTP-binding protein Rheb
The deposited structure of PDB entry 1xts contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in GTP-binding protein Rheb. Showing 1 copy in chain A.
SCOP SCOP annotation
52592
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. GTP-binding protein Rheb
The deposited structure of PDB entry 1xts contains 1 copy of SCOP domain 52592 (G proteins) in GTP-binding protein Rheb. Showing 1 copy in chain A.