PDBe 1xtc

X-ray diffraction
2.4Å resolution

CHOLERA TOXIN

Released:
Source organism: Vibrio cholerae 569B

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cholera enterotoxin subunit A1 Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 21.84 KDa
Source organism: Vibrio cholerae 569B
UniProt:
  • Canonical: P01555 (Residues: 19-212; Coverage: 81%)
Gene names: VC_1457, ctxA, toxA
Structure domains: Heat-Labile Enterotoxin, subunit A
Cholera enterotoxin subunit A2 Chain: C
Molecule details ›
Chain: C
Length: 46 amino acids
Theoretical weight: 5.4 KDa
Source organism: Vibrio cholerae 569B
UniProt:
  • Canonical: P01555 (Residues: 213-258; Coverage: 19%)
Gene names: VC_1457, ctxA, toxA
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Cholera enterotoxin subunit B Chains: D, E, F, G, H
Molecule details ›
Chains: D, E, F, G, H
Length: 103 amino acids
Theoretical weight: 11.69 KDa
Source organism: Vibrio cholerae 569B
UniProt:
  • Canonical: P01556 (Residues: 22-124; Coverage: 100%)
Gene names: VC_1456, ctxB, toxB
Sequence domains: Heat-labile enterotoxin beta chain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 73Å b: 92.2Å c: 60.6Å
α: 90° β: 106.4° γ: 90°
R-values:
R R work R free
0.185 0.185 not available