PDBe 1xq7

X-ray diffraction
2.07Å resolution

Cyclophilin from Trypanosoma cruzi bound to cyclosporin A

Released:
Entry authors: Caruthers JM, Hol WGJ, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CYCLOSPORIN A Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided
Peptidyl-prolyl cis-trans isomerase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 166 amino acids
Theoretical weight: 18.06 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4DPB9 (Residues: 30-194; Coverage: 99%)
Gene name: Tc00.1047053508577.140
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

No bound ligands

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P1
Unit cell:
a: 52.269Å b: 57.059Å c: 58.807Å
α: 110.49° β: 108.21° γ: 105.4°
R-values:
R R work R free
0.172 0.169 0.235
Expression systems:
  • Not provided
  • Escherichia coli