PDBe 1xog

X-ray diffraction
2.8Å resolution

N9 Tern Influenza neuraminidase complexed with a 2,5-Disubstituted tetrahydrofuran-5-carboxylic acid


Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Neuraminidase Chain: A
Molecule details ›
Chain: A
Length: 387 amino acids
Theoretical weight: 43.57 KDa
Source organism: Influenza A virus
  • Canonical: P03472 (Residues: 84-470; Coverage: 82%)
Gene name: NA
Structure domains: Neuraminidase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: I432
Unit cell:
a: 180.344Å b: 180.344Å c: 180.344Å
α: 90° β: 90° γ: 90°
R R work R free
0.221 0.221 0.297