PDBe 1xf9

X-ray diffraction
2.7Å resolution

Structure of NBD1 from murine CFTR- F508S mutant

Released:
Source organism: Mus musculus
Primary publication:
Side chain and backbone contributions of Phe508 to CFTR folding.
Nat. Struct. Mol. Biol. 12 10-6 (2005)
PMID: 15619636

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexamer
homo octamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystic fibrosis transmembrane conductance regulator Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 283 amino acids
Theoretical weight: 31.71 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P26361 (Residues: 389-670; Coverage: 19%)
Gene names: Abcc7, Cftr
Sequence domains: ABC transporter
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P4212
Unit cell:
a: 170.449Å b: 170.449Å c: 109.065Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.201 0.253
Expression system: Escherichia coli