PDBe 1xev

X-ray diffraction
2.2Å resolution

Crystal structure of human carbonic anhydrase II in a new crystal form

Released:
Source organism: Homo sapiens
Entry authors: Mazumdar PA, Kumaran D, Das AK, Swaminathan S

Function and Biology Details

Reaction catalysed:
H(2)CO(3) = CO(2) + H(2)O. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 260 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Carbonic Anhydrase II

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 45.706Å b: 147.1Å c: 76.446Å
α: 90° β: 91.33° γ: 90°
R-values:
R R work R free
0.21 0.21 0.26
Expression system: Escherichia coli BL21(DE3)