PDBe 1xeg

X-ray diffraction
1.81Å resolution

Crystal structure of human carbonic anhydrase II complexed with an acetate ion

Released:
Source organism: Homo sapiens
Primary publication:
A novel acetate-bound complex of human carbonic anhydrase II.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 163-6 (2008)
PMID: 18323598

Function and Biology Details

Reaction catalysed:
H(2)CO(3) = CO(2) + H(2)O. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Carbonic Anhydrase II

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 42.312Å b: 71.749Å c: 74.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.18 0.21
Expression system: Escherichia coli BL21(DE3)