PDBe 1x6c

Solution NMR

Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1

Released:
Source organism: Homo sapiens
Entry authors: Sato M, Koshiba S, Inoue M, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 6 Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P29350 (Residues: 110-214; Coverage: 18%)
Gene names: HCP, PTP1C, PTPN6
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided