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E.coli NAD Synthetase, NAD

Source organism: Escherichia coli
Biochemical function: metal ion binding
Biological process: 'de novo' NAD biosynthetic process from aspartate
Cellular component: cytosol

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EC 6.3.1.5: NAD(+) synthase

Reaction catalysed:
ATP + deamido-NAD(+) + NH(3) = AMP + diphosphate + NAD(+)
Systematic name:
Deamido-NAD(+):ammonia ligase (AMP-forming)
Alternative Name(s):
  • Diphosphopyridine nucleotide synthetase
  • NAD synthetase
  • NAD(+) synthetase
  • Nicotinamide adenine dinucleotide synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02540
Domain description: NAD synthase
Occurring in:
  1. NH(3)-dependent NAD(+) synthetase
The deposited structure of PDB entry 1wxh contains 1 copy of Pfam domain PF02540 (NAD synthase) in NH(3)-dependent NAD(+) synthetase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003694
Domain description: NAD(+) synthetase
Occurring in:
  1. NH(3)-dependent NAD(+) synthetase
IPR022310
Domain description: NAD/GMP synthase
Occurring in:
  1. NH(3)-dependent NAD(+) synthetase
IPR022926
Domain description: NH(3)-dependent NAD(+) synthetase
Occurring in:
  1. NH(3)-dependent NAD(+) synthetase
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. NH(3)-dependent NAD(+) synthetase

Structure domain

CATH CATH domain
3.40.50.620
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HUPs
Occurring in:
  1. NH(3)-dependent NAD(+) synthetase
The deposited structure of PDB entry 1wxh contains 1 copy of CATH domain 3.40.50.620 (Rossmann fold) in NH(3)-dependent NAD(+) synthetase. Showing 1 copy in chain A.
SCOP SCOP annotation
52403
Class: Alpha and beta proteins (a/b)
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Adenine nucleotide alpha hydrolases-like
Occurring in:
  1. NH(3)-dependent NAD(+) synthetase
The deposited structure of PDB entry 1wxh contains 1 copy of SCOP domain 52403 (N-type ATP pyrophosphatases) in NH(3)-dependent NAD(+) synthetase. Showing 1 copy in chain A.

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