PDBe 1www

X-ray diffraction
2.2Å resolution

NGF IN COMPLEX WITH DOMAIN 5 OF THE TRKA RECEPTOR

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Beta-nerve growth factor Chains: V, W
Molecule details ›
Chains: V, W
Length: 120 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01138 (Residues: 122-241; Coverage: 54%)
Gene names: NGF, NGFB
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines
High affinity nerve growth factor receptor Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 101 amino acids
Theoretical weight: 11.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04629 (Residues: 282-382; Coverage: 13%)
Gene names: MTC, NTRK1, TRK, TRKA
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 58.245Å b: 53.735Å c: 77.101Å
α: 90° β: 107.34° γ: 90°
R-values:
R R work R free
0.189 0.189 0.266
Expression system: Escherichia coli