PDBe 1wvx

X-ray diffraction
2.6Å resolution

Crystal structures of kinase domain of DAP kinase in complex with small molecular inhibitors

Released:
Source organism: Homo sapiens
Entry authors: Ueda Y, Ogata H, Yamakawa A, Higuchi Y

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Death-associated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 278 amino acids
Theoretical weight: 31.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P53355 (Residues: 1-278; Coverage: 19%)
Gene names: DAPK, DAPK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 77.337Å b: 108.869Å c: 50.186Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 0.27
Expression system: Escherichia coli BL21(DE3)