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crystal structure of human galactokinase complexed with MgAMPPNP and galactose

X-ray diffraction
2.5Å resolution
PDB entry 1wuu coloured by chain, front view.
PDB entry 1wuu coloured by chain, side view.
PDB entry 1wuu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Galactokinase
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Multimeric state: homo dimer
Accessible surface area: 30084.8 Å2
Buried surface area: 4236.83 Å2
Dissociation area: 701.46 Å2
Dissociation energy (ΔGdiss): -1.74 kcal/mol
Dissociation entropy (TΔSdiss): 13.99 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-156361
Assembly 2
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Assembly Name: Galactokinase
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Multimeric state: homo dimer
Accessible surface area: 29773.65 Å2
Buried surface area: 4494.51 Å2
Dissociation area: 837.07 Å2
Dissociation energy (ΔGdiss): 0.57 kcal/mol
Dissociation entropy (TΔSdiss): 14.03 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-156361

Macromolecules

Galactokinase
Chains: A, B, C, D
Length: 399 amino acids
Theoretical weight: 43.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51570 (Residues: 2-392; Coverage: 100%)
Gene names: GALK, GALK1
Pfam:
InterPro:
CATH:
SCOP:
Galactokinase in PDB entry 1wuu, assembly 1, front view.
Galactokinase in PDB entry 1wuu, assembly 1, side view.
Galactokinase in PDB entry 1wuu, assembly 1, top view.
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