PDBe 1wrl

X-ray diffraction
2.6Å resolution

Crystal structure of the N-terminal domain of human cardiac troponin C in complex with trifluoperazine (monoclinic crystal form)

Released:
Source organism: Homo sapiens
Entry authors: Takeda S, Igarashi T, Oishi Y, Mori H

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 88 amino acids
Theoretical weight: 9.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 1-88; Coverage: 55%)
Gene names: TNNC, TNNC1
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL45PX
Spacegroup: P21
Unit cell:
a: 48.93Å b: 67.46Å c: 90.28Å
α: 90° β: 96.75° γ: 90°
R-values:
R R work R free
0.242 0.24 0.273
Expression system: Escherichia coli