PDBe 1wqu

Solution NMR

Solution structure of the human FES SH2 domain

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fes/Fps Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 12.51 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P07332 (Residues: 450-550; Coverage: 12%)
Gene names: FES, FPS
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 92%
Refinement method: automated NOESY assignment, torsion angle dynamics, energy minimization
Chemical shifts: BMR6331  
Expression system: Not provided