PDBe 1wqj

X-ray diffraction
1.6Å resolution

Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin-like growth factor I Chain: I
Molecule details ›
Chain: I
Length: 70 amino acids
Theoretical weight: 7.66 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05019 (Residues: 49-118; Coverage: 40%)
Gene names: IBP1, IGF1
Sequence domains: Insulin/IGF/Relaxin family
Structure domains: Insulin-like, subunit E
Insulin-like growth factor-binding protein 4 Chain: B
Molecule details ›
Chain: B
Length: 80 amino acids
Theoretical weight: 8.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22692 (Residues: 24-103; Coverage: 34%)
Gene names: IBP4, IGFBP4
Sequence domains: Insulin-like growth factor binding protein

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P212121
Unit cell:
a: 34.47Å b: 54.28Å c: 74.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.184 0.255
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)