PDBe 1wm0

X-ray diffraction
2.9Å resolution

PPARgamma in complex with a 2-BABA compound

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor coactivator 2 Chain: Y
Molecule details ›
Chain: Y
Length: 14 amino acids
Theoretical weight: 1.75 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q61026 (Residues: 684-697; Coverage: 1%)
Gene names: Grip1, Ncoa2, Src2, Tif2
Peroxisome proliferator-activated receptor gamma Chain: X
Molecule details ›
Chain: X
Length: 292 amino acids
Theoretical weight: 33.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 232-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 49.166Å b: 66.324Å c: 122.671Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.191 0.295
Expression systems:
  • Not provided
  • Escherichia coli BL21(DE3)