PDBe 1wa7

Solution NMR

SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE IN COMPLEX WITH A HERPESVIRAL LIGAND

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase Lyn Chain: A
Molecule details ›
Chain: A
Length: 65 amino acids
Theoretical weight: 7.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P07948 (Residues: 60-123; Coverage: 13%)
Gene names: JTK8, LYN
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Tyrosine-protein kinase-interacting protein Chain: B
Molecule details ›
Chain: B
Length: 22 amino acids
Theoretical weight: 2.4 KDa
Source organism: Saimiriine gammaherpesvirus 2
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P22575 (Residues: 170-191; Coverage: 9%)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: XPLOR
Chemical shifts: BMR6456  
Expression system: Escherichia coli BL21