PDBe 1w98

X-ray diffraction
2.15Å resolution

The structural basis of CDK2 activation by cyclin E

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
G1/S-specific cyclin-E1 Chain: B
Molecule details ›
Chain: B
Length: 283 amino acids
Theoretical weight: 32.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24864 (Residues: 96-378; Coverage: 69%)
Gene names: CCNE, CCNE1
Sequence domains:
Structure domains: Cyclin A; domain 1
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 34.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-297; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P41212
Unit cell:
a: 99.62Å b: 99.62Å c: 149.987Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.181 0.246
Expression system: Escherichia coli