Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Non-structural protein 4A (preferred)
PDBe Complex ID:
PDB-CPX-150801 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine protease/helicase NS3
Molecule details ›
Chains: A, B
Length: 187 amino acids
Theoretical weight: 19.75 KDa
Source organism: Hepatitis C virus (isolate 1)
Expression system: Escherichia coli
UniProt:
Structure domains:
Length: 187 amino acids
Theoretical weight: 19.75 KDa
Source organism: Hepatitis C virus (isolate 1)
Expression system: Escherichia coli
UniProt:
- Canonical:
P26662 (Residues: 1027-1213; Coverage: 6%)
Structure domains:
Non-structural protein 4A
Molecule details ›
Chains: C, D
Length: 16 amino acids
Theoretical weight: 1.69 KDa
Source organism: Hepatitis C virus (isolate 1)
Expression system: Not provided
UniProt:
Length: 16 amino acids
Theoretical weight: 1.69 KDa
Source organism: Hepatitis C virus (isolate 1)
Expression system: Not provided
UniProt:
- Canonical: P26662 (Residues: 1677-1692; Coverage: 1%)
