PDBe 1w1x

X-ray diffraction
2Å resolution

Structure of Neuraminidase from English duck subtype N6 complexed with 30 mM sialic acid (NANA, Neu5Ac), crystal soaked for 3 hours at 277 K.

Released:
Source organism: Influenza A virus
Entry authors: Rudino-Pinera E, Tunnah P, Crennell SJ, Webster RG, Laver WG, Garman EF

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuraminidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 389 amino acids
Theoretical weight: 43.01 KDa
Source organism: Influenza A virus
Expression system: Gallus gallus
UniProt:
  • Canonical: Q6XV27 (Residues: 82-470; Coverage: 83%)
Gene name: NA
Structure domains: Neuraminidase

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P21
Unit cell:
a: 106.993Å b: 73.464Å c: 107.413Å
α: 90° β: 90.38° γ: 90°
R-values:
R R work R free
0.167 0.164 0.207
Expression system: Gallus gallus