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Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP

X-ray diffraction
1.59Å resolution
PDB entry 1w0h coloured by chain, front view.
PDB entry 1w0h coloured by chain, side view.
PDB entry 1w0h coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 3'-5' exoribonuclease 1
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-184862

Macromolecules

3'-5' exoribonuclease 1
Chain: A
Length: 204 amino acids
Theoretical weight: 24.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IV48 (Residues: 120-322; Coverage: 58%)
Gene names: 3'EXO, ERI1, THEX1
Pfam: Exonuclease
InterPro:
CATH: Ribonuclease H-like superfamily/Ribonuclease H
SCOP: DnaQ-like 3'-5' exonuclease
3'-5' exoribonuclease 1 in PDB entry 1w0h, assembly 1, front view.
3'-5' exoribonuclease 1 in PDB entry 1w0h, assembly 1, side view.
3'-5' exoribonuclease 1 in PDB entry 1w0h, assembly 1, top view.
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