PDBe 1w0h

X-ray diffraction
1.59Å resolution

Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP

Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
3'-5' exoribonuclease 1 Chain: A
Molecule details ›
Chain: A
Length: 204 amino acids
Theoretical weight: 24.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q8IV48 (Residues: 120-322; Coverage: 58%)
Gene names: 3'EXO, ERI1, THEX1
Sequence domains: Exonuclease
Structure domains: Nucleotidyltransferase; domain 5

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P6122
Unit cell:
a: 101.6Å b: 101.6Å c: 100.4Å
α: 90° β: 90° γ: 120°
R R work R free
0.17 0.168 0.202
Expression system: Escherichia coli BL21(DE3)