Assemblies
Assembly Name:
alpha-thrombin complex and Hirudin-2
Multimeric state:
hetero trimer
Accessible surface area:
12733.94 Å2
Buried surface area:
4127.53 Å2
Dissociation area:
426.75
Å2
Dissociation energy (ΔGdiss):
-0.24
kcal/mol
Dissociation entropy (TΔSdiss):
6.38
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-133087
Macromolecules
Chain: H
Length: 250 amino acids
Theoretical weight: 28.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Pfam: Trypsin
InterPro:
Length: 250 amino acids
Theoretical weight: 28.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P00734 (Residues: 364-620; Coverage: 42%)
Pfam: Trypsin
InterPro:
- Serine proteases, trypsin domain
- Peptidase S1, PA clan
- Peptidase S1, PA clan, chymotrypsin-like fold
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin family, histidine active site
- Prothrombin/thrombin
- Serine proteases, trypsin family, serine active site
Chain: I
Length: 11 amino acids
Theoretical weight: 1.41 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
Length: 11 amino acids
Theoretical weight: 1.41 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
- Canonical: P28504 (Residues: 55-65; Coverage: 17%)
Chain: L
Length: 27 amino acids
Theoretical weight: 3.19 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Pfam: Thrombin light chain
InterPro:
Length: 27 amino acids
Theoretical weight: 3.19 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical: P00734 (Residues: 334-360; Coverage: 5%)
Pfam: Thrombin light chain
InterPro:
