PDBe 1vzo

X-ray diffraction
1.8Å resolution

The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-5 Chain: A
Molecule details ›
Chain: A
Length: 355 amino acids
Theoretical weight: 39.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75582 (Residues: 2-348; Coverage: 43%)
Gene names: MSK1, RPS6KA5
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 66.629Å b: 73.772Å c: 89.118Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 0.242
Expression system: Spodoptera frugiperda