PDBe 1vie

X-ray diffraction
1.7Å resolution

STRUCTURE OF DIHYDROFOLATE REDUCTASE

Released:

Function and Biology Details

Reaction catalysed:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydrofolate reductase type 2 Chain: A
Molecule details ›
Chain: A
Length: 62 amino acids
Theoretical weight: 6.73 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P00383 (Residues: 17-78; Coverage: 80%)
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: I4122
Unit cell:
a: 68.74Å b: 68.74Å c: 52.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 not available
Expression system: Escherichia coli