PDBe 1vhr

X-ray diffraction
2.1Å resolution

HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of the dual specificity protein phosphatase VHR.
Science 272 1328-31 (1996)
PMID: 8650541

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein phosphatase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 184 amino acids
Theoretical weight: 20.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51452 (Residues: 2-185; Coverage: 100%)
Gene names: DUSP3, VHR
Sequence domains: Dual specificity phosphatase, catalytic domain
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 61.148Å b: 60.04Å c: 52.016Å
α: 90° β: 98.35° γ: 90°
R-values:
R R work R free
0.176 0.176 0.254
Expression system: Escherichia coli BL21(DE3)