› 1vfz

X-ray diffraction
2.24Å resolution

Crystal Structure of the Kif1A Motor Domain Complexed With ADP-Mg-VO4

Released:
DOI: 10.2210/pdb1vfz/pdb
PDB entry 1vfz coloured by chain, front view.
PDB entry 1vfz coloured by chain, side view.
PDB entry 1vfz coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
KIF1A alternately uses two loops to bind microtubules.
Nitta R, Kikkawa M, Okada Y, Hirokawa N
Science 305 678-83 (2004)
PMID: 15286375

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152547 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF1A Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 41.13 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P33173 (Residues: 1-361; Coverage: 21%)
Gene names: Atsv, Kif1, Kif1a
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

3 bound ligands:
Ligand VO4 1 x VO4
Ligand MG 1 x MG
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P212121
Unit cell:
a: 41.471Å b: 51.805Å c: 156.992Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.215 0.249
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Molecular motors and mechanisms of directional transport in neurons.
Hirokawa et al. (2005)
14 more

6 mentions without citation

Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis.
Erlich et al. (2011)
5 more