PDBe 1v0p

X-ray diffraction
2Å resolution

Structure of P. falciparum PfPK5-Purvalanol B ligand complex


Function and Biology Details

Reactions catalysed:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. 
ATP + a protein = ADP + a phosphoprotein. 
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cell division control protein 2 homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 288 amino acids
Theoretical weight: 33.06 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
  • Canonical: Q07785 (Residues: 1-288; Coverage: 100%)
Gene names: CRK2, PK5
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 222.64Å b: 44.361Å c: 63.762Å
α: 90° β: 103.19° γ: 90°
R R work R free
0.198 0.194 0.265
Expression system: Escherichia coli