PDBe 1v0o

X-ray diffraction
1.9Å resolution

Structure of P. falciparum PfPK5-Indirubin-5-sulphonate ligand complex

Released:

Function and Biology Details

Reactions catalysed:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. 
ATP + a protein = ADP + a phosphoprotein. 
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell division control protein 2 homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 288 amino acids
Theoretical weight: 33.04 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07785 (Residues: 1-288; Coverage: 100%)
Gene names: CRK2, PK5
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 60.562Å b: 88.277Å c: 63.857Å
α: 90° β: 97.33° γ: 90°
R-values:
R R work R free
0.233 0.233 0.282
Expression system: Escherichia coli