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Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide

X-ray diffraction
1.8Å resolution
PDB entry 1uvq coloured by chain, front view.
PDB entry 1uvq coloured by chain, side view.
PDB entry 1uvq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18608.49 Å2
Buried surface area: 9437.02 Å2
Dissociation area: 1,408.15 Å2
Dissociation energy (ΔGdiss): 14.6 kcal/mol
Dissociation entropy (TΔSdiss): 9.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-123202

Macromolecules

Ig-like domain-containing protein
Chain: A
Length: 197 amino acids
Theoretical weight: 22.28 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: E9PMV2 (Residues: 24-204; Coverage: 95%)
Gene name: HLA-DQA1
Pfam:
InterPro:
CATH:
SCOP:
Ig-like domain-containing protein in PDB entry 1uvq, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 1uvq, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 1uvq, assembly 1, top view.
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HLA class II histocompatibility antigen, DQ beta 1 chain
Chain: B
Length: 198 amino acids
Theoretical weight: 23.03 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01920 (Residues: 35-231; Coverage: 86%)
Gene names: HLA-DQB, HLA-DQB1
Pfam:
InterPro:
CATH:
SCOP:
HLA class II histocompatibility antigen, DQ beta 1 chain in PDB entry 1uvq, assembly 1, front view.
HLA class II histocompatibility antigen, DQ beta 1 chain in PDB entry 1uvq, assembly 1, side view.
HLA class II histocompatibility antigen, DQ beta 1 chain in PDB entry 1uvq, assembly 1, top view.
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Hypocretin neuropeptide precursor
Chain: C
Length: 33 amino acids
Theoretical weight: 3.1 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: O43612 (Residues: 1-13; Coverage: 0%)
Gene names: HCRT, OX, PPORX, PPOX
Hypocretin neuropeptide precursor in PDB entry 1uvq, assembly 1, front view.
Hypocretin neuropeptide precursor in PDB entry 1uvq, assembly 1, side view.
Hypocretin neuropeptide precursor in PDB entry 1uvq, assembly 1, top view.
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