PDBe 1uvq

X-ray diffraction
1.8Å resolution

Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Orexin Chain: C
Molecule details ›
Chain: C
Length: 33 amino acids
Theoretical weight: 3.1 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: O43612 (Residues: 1-13; Coverage: 0%)
Gene names: HCRT, OX, PPORX, PPOX
HLA class II histocompatibility antigen, DQ alpha 1 chain Chain: A
Molecule details ›
Chain: A
Length: 197 amino acids
Theoretical weight: 22.28 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: E9PMV2 (Residues: 24-204; Coverage: 95%)
Gene name: HLA-DQA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DQ beta 1 chain Chain: B
Molecule details ›
Chain: B
Length: 198 amino acids
Theoretical weight: 23.03 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01920 (Residues: 35-231; Coverage: 86%)
Gene names: HLA-DQB, HLA-DQB1
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21212
Unit cell:
a: 102.078Å b: 129.304Å c: 40.619Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.189 0.205
Expression system: Drosophila melanogaster