PDBe 1uu9

X-ray diffraction
1.95Å resolution

Structure of human PDK1 kinase domain in complex with BIM-3

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-phosphoinositide-dependent protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 286 amino acids
Theoretical weight: 33.14 KDa
Source organism: Spodoptera frugiperda
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15530 (Residues: 72-357; Coverage: 51%)
Gene names: PDK1, PDPK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P3221
Unit cell:
a: 121.629Å b: 121.629Å c: 48.018Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.183 0.224
Expression system: Spodoptera frugiperda