PDBe 1usx

X-ray diffraction
2.7Å resolution

Crystal structure of the Newcastle disease virus hemagglutinin-neuraminidase complexed with thiosialoside

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin-neuraminidase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 454 amino acids
Theoretical weight: 49.86 KDa
Source organism: Avian avulavirus 1
UniProt:
  • Canonical: P32884 (Residues: 124-577; Coverage: 79%)
Gene name: HN
Structure domains: Neuraminidase

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P41212
Unit cell:
a: 115.07Å b: 115.07Å c: 283.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.225 0.289