PDBe 1usr

X-ray diffraction
2Å resolution

Newcastle disease virus hemagglutinin-neuraminidase: Evidence for a second sialic acid binding site and implications for fusion

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin-neuraminidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 454 amino acids
Theoretical weight: 49.86 KDa
Source organism: Avian avulavirus 1
UniProt:
  • Canonical: P32884 (Residues: 124-577; Coverage: 79%)
Gene name: HN
Structure domains: Neuraminidase

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P21212
Unit cell:
a: 175.48Å b: 99.26Å c: 64.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.226