PDBe 1uro

X-ray diffraction
1.8Å resolution

UROPORPHYRINOGEN DECARBOXYLASE

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of human uroporphyrinogen decarboxylase.
EMBO J. 17 2463-71 (1998)
PMID: 9564029

Function and Biology Details

Reaction catalysed:
Uroporphyrinogen III = coproporphyrinogen + 4 CO(2). 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uroporphyrinogen decarboxylase Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 40.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P06132 (Residues: 1-367; Coverage: 100%)
Gene name: UROD
Sequence domains: Uroporphyrinogen decarboxylase (URO-D)
Structure domains: TIM Barrel

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P3121
Unit cell:
a: 103Å b: 103Å c: 73.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.184 0.233
Expression system: Escherichia coli BL21