› › Function and Biology

Trehalose-6-phosphate from E. coli bound with UDP-2-fluoro glucose.

Source organism: Escherichia coli
Biochemical function: hexosyltransferase activity
Biological process: trehalose metabolism in response to cold stress
Cellular component: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)

Quick links

EC 2.4.1.15: Alpha,alpha-trehalose-phosphate synthase (UDP-forming)

Reaction catalysed:
UDP-alpha-D-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate
Systematic name:
UDP-alpha-D-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase (configuration-retaining)
Alternative Name(s):
  • Alpha,alpha-trehalose phosphate synthase (UDP-forming)
  • Phosphotrehalose-uridine diphosphate transglucosylase
  • Transglucosylase
  • Trehalose 6-phosphate synthase
  • Trehalose 6-phosphate synthetase
  • Trehalose phosphate synthase
  • Trehalose phosphate synthetase
  • Trehalose phosphate-uridine diphosphate glucosyltransferase
  • Trehalose-P synthetase
  • Trehalosephosphate-UDP glucosyltransferase
  • UDP-glucose--glucose-phosphate glucosyltransferase
  • UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase
  • Uridine diphosphoglucose phosphate glucosyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00982
Domain description: Glycosyltransferase family 20
Occurring in:
  1. Trehalose-6-phosphate synthase
The deposited structure of PDB entry 1uqt contains 2 copies of Pfam domain PF00982 (Glycosyltransferase family 20) in Trehalose-6-phosphate synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001830
Domain description: Glycosyl transferase, family 20
Occurring in:
  1. Trehalose-6-phosphate synthase
IPR012766
Domain description: Alpha,alpha-trehalose-phosphate synthase
Occurring in:
  1. Trehalose-6-phosphate synthase

Structure domain

CATH CATH domain
3.40.50.2000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Glycogen Phosphorylase B;
Occurring in:
  1. Trehalose-6-phosphate synthase
The deposited structure of PDB entry 1uqt contains 4 copies of CATH domain 3.40.50.2000 (Rossmann fold) in Trehalose-6-phosphate synthase. Showing 2 copies in chain A.
SCOP SCOP annotation
82540
Class: Alpha and beta proteins (a/b)
Fold: UDP-Glycosyltransferase/glycogen phosphorylase
Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase
Occurring in:
  1. Trehalose-6-phosphate synthase
The deposited structure of PDB entry 1uqt contains 2 copies of SCOP domain 82540 (Trehalose-6-phosphate synthase, OtsA) in Trehalose-6-phosphate synthase. Showing 1 copy in chain A.

Quick links