PDBe 1upw

X-ray diffraction
2.4Å resolution

Crystal structure of the human Liver X receptor beta ligand binding domain in complex with a synthetic agonist

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxysterols receptor LXR-beta Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 29.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P55055 (Residues: 203-460; Coverage: 56%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 137.22Å b: 43.276Å c: 51.615Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.25 0.295
Expression system: Escherichia coli BL21