EC 2.7.11.1: Non-specific serine/threonine protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
- A-kinase
- AP50 kinase
- ATP-protein transphosphorylase
- Beta-IIPKC
- Beta-adrenergic receptor kinase
- CK-2
- CKI
- CKII
- Calcium-dependent protein kinase C
- Calcium/phospholipid-dependent protein kinase
- Casein kinase
- Casein kinase (phosphorylating)
- Casein kinase 2
- Casein kinase I
- Casein kinase II
- Cyclic AMP-dependent protein kinase
- Cyclic AMP-dependent protein kinase A
- Cyclic monophosphate-dependent protein kinase
- Cyclic nucleotide-dependent protein kinase
- Cyclin-dependent kinase
- Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
- Dsk1
- Epsilon PKC
- Glycogen synthase A kinase
- Glycogen synthase a kinase
- Glycogen synthase kinase
- HIPK2
- Hpr kinase
- Hydroxyalkyl-protein kinase
- M phase-specific cdc2 kinase
- MAPK
- Mitogen-activated S6 kinase
- Mitogen-activated protein kinase
- P82 kinase
- PKA
- PKC
- Phosphorylase B kinase kinase
- Phosphorylase b kinase kinase
- Phosphorylase b kinase kinase
- Protein glutamyl kinase
- Protein kinase (phosphorylating)
- Protein kinase A
- Protein kinase CK2
- Protein kinase p58
- Protein phosphokinase
- Protein serine kinase
- Protein serine-threonine kinase
- Protein-aspartyl kinase
- Protein-cysteine kinase
- Protein-serine kinase
- Prp4 protein kinase
- Raf kinase
- Raf-1
- Ribosomal S6 protein kinase
- Ribosomal protein S6 kinase II
- STK32
- Serine kinase
- Serine protein kinase
- Serine(threonine) protein kinase
- Serine-specific protein kinase
- Serine/threonine protein kinase
- T-antigen kinase
- Threonine-specific protein kinase
- Twitchin kinase
- Type-2 casein kinase
- WEE1Hu
- Wee 1-like kinase
- Wee-kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase A
- cGMP-dependent protein kinase
GO terms
Biochemical function:
- cyclin-dependent protein serine/threonine kinase activator activity
- protein serine kinase activity
- Hsp90 protein binding
- tau-protein kinase activity
- tau protein binding
- ErbB-3 class receptor binding
- acetylcholine receptor activator activity
- transferase activity
- kinase activity
- microtubule binding
- ATP binding
- protein binding
- ErbB-2 class receptor binding
- cyclin-dependent protein serine/threonine kinase activity
- protein serine/threonine kinase activity
- protein kinase activity
- p53 binding
- nucleotide binding
Biological process:
- obsolete positive regulation of actin cytoskeleton reorganization
- cellular response to amyloid-beta
- regulation of synaptic vesicle recycling
- regulation of protein localization to plasma membrane
- positive regulation of protein targeting to membrane
- calcium ion import
- regulation of dendritic spine morphogenesis
- excitatory postsynaptic potential
- regulation of postsynaptic membrane potential
- regulation of synaptic transmission, glutamatergic
- regulation of cell cycle
- establishment of localization in cell
- neuron apoptotic process
- cell division
- dendrite morphogenesis
- oligodendrocyte differentiation
- axon extension
- rhythmic process
- synaptic vesicle transport
- synaptic vesicle endocytosis
- regulation of synaptic plasticity
- behavioral response to cocaine
- negative regulation of protein export from nucleus
- positive regulation of calcium ion-dependent exocytosis
- negative regulation of DNA-templated transcription
- negative regulation of proteolysis
- negative regulation of cell cycle
- positive regulation of neuron apoptotic process
- receptor clustering
- regulation of apoptotic process
- response to cocaine
- protein localization to synapse
- synaptic transmission, glutamatergic
- receptor catabolic process
- negative regulation of synaptic plasticity
- negative regulation of protein ubiquitination
- neuron projection development
- forebrain development
- negative regulation of axon extension
- regulation of cell migration
- neuron differentiation
- corpus callosum development
- cerebral cortex development
- central nervous system neuron development
- layer formation in cerebral cortex
- hippocampus development
- cerebellar cortex formation
- cerebellar cortex development
- cerebellum development
- telencephalon development
- sensory perception of pain
- peptidyl-threonine phosphorylation
- peptidyl-serine phosphorylation
- cell migration
- phosphorylation
- regulation of macroautophagy
- vesicle-mediated transport
- synaptic vesicle exocytosis
- Schwann cell development
- visual learning
- associative learning
- motor neuron axon guidance
- skeletal muscle tissue development
- synapse assembly
- axonogenesis
- nervous system development
- chemical synaptic transmission
- cell-matrix adhesion
- cell cycle
- apoptotic process
- intracellular protein transport
- protein phosphorylation
- synaptic transmission, dopaminergic
- neuron migration
- microtubule cytoskeleton organization
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 1unh contains 2 copies of Pfam domain PF03261 (Cyclin-dependent kinase 5 activator protein) in Cyclin-dependent kinase 5 activator 1, p25. Showing 1 copy in chain C [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/1unh_2_D_Pfam_PF03261_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF03261 (Cyclin-dependent kinase 5 activator protein)</span> in <span class='highlight'>Cyclin-dependent kinase 5 activator 1, p25</span>. Showing 1 copy in chain <span class='highlight'>C [auth D]</span>.")
InterPro annotations
Structure domains
CATH domains
1.10.472.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Cyclin A; domain 1
Homology:
Cyclin-like
Occurring in:
![The deposited structure of PDB entry 1unh contains 2 copies of CATH domain 1.10.472.10 (Cyclin A; domain 1) in Cyclin-dependent kinase 5 activator 1, p25. Showing 1 copy in chain C [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/1unh_2_D_CATH_1.10.472.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1unh</span> contains 2 copies of CATH domain <span class='highlight'>1.10.472.10 (Cyclin A; domain 1)</span> in <span class='highlight'>Cyclin-dependent kinase 5 activator 1, p25</span>. Showing 1 copy in chain <span class='highlight'>C [auth D]</span>.")
1.10.510.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Transferase(Phosphotransferase); domain 1
Homology:
Transferase(Phosphotransferase) domain 1
Occurring in:
SCOP annotations![The deposited structure of PDB entry 1unh contains 2 copies of SCOP domain 47955 (Cyclin) in Cyclin-dependent kinase 5 activator 1, p25. Showing 1 copy in chain C [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/1unh_2_D_SCOP_47955_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1unh</span> contains 2 copies of SCOP domain <span class='highlight'>47955 (Cyclin)</span> in <span class='highlight'>Cyclin-dependent kinase 5 activator 1, p25</span>. Showing 1 copy in chain <span class='highlight'>C [auth D]</span>.")
