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Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

X-ray diffraction
2.7Å resolution
PDB entry 1uki coloured by chain, front view.
PDB entry 1uki coloured by chain, side view.
PDB entry 1uki coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 8 and C-Jun-amino-terminal kinase-interacting protein 1
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Multimeric state: hetero dimer
Accessible surface area: 15935.41 Å2
Buried surface area: 1641.88 Å2
Dissociation area: 568.1 Å2
Dissociation energy (ΔGdiss): 2.34 kcal/mol
Dissociation entropy (TΔSdiss): 7.65 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155387

Macromolecules

Mitogen-activated protein kinase 8
Chain: A
Length: 369 amino acids
Theoretical weight: 42.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45983 (Residues: 1-363; Coverage: 85%)
Gene names: JNK1, MAPK8, PRKM8, SAPK1, SAPK1C
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Mitogen-activated protein kinase 8 in PDB entry 1uki, assembly 1, front view.
Mitogen-activated protein kinase 8 in PDB entry 1uki, assembly 1, side view.
Mitogen-activated protein kinase 8 in PDB entry 1uki, assembly 1, top view.
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C-Jun-amino-terminal kinase-interacting protein 1
Chain: B
Length: 11 amino acids
Theoretical weight: 1.35 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q9WVI9 (Residues: 153-163; Coverage: 2%)
Gene names: Ib1, Jip1, Mapk8ip, Mapk8ip1, Prkm8ip
C-Jun-amino-terminal kinase-interacting protein 1 in PDB entry 1uki, assembly 1, front view.
C-Jun-amino-terminal kinase-interacting protein 1 in PDB entry 1uki, assembly 1, side view.
C-Jun-amino-terminal kinase-interacting protein 1 in PDB entry 1uki, assembly 1, top view.
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