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Crystal Structure of STAM2 SH3 domain in complex with a UBPY-derived peptide

X-ray diffraction
1.7Å resolution
PDB entry 1uj0 coloured by chain, front view.
PDB entry 1uj0 coloured by chain, side view.
PDB entry 1uj0 coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Signal transducing adapter molecule 2 and Ubiquitin carboxyl-terminal hydrolase 8
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Multimeric state: hetero dimer
Accessible surface area: 4244.08 Å2
Buried surface area: 1000.31 Å2
Dissociation area: 430.03 Å2
Dissociation energy (ΔGdiss): -0.37 kcal/mol
Dissociation entropy (TΔSdiss): 6.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131585

Macromolecules

Signal transducing adapter molecule 2
Chain: A
Length: 62 amino acids
Theoretical weight: 7.06 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O88811 (Residues: 204-261; Coverage: 11%)
Gene names: Hbp, Stam2
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
SCOP: SH3-domain
Signal transducing adapter molecule 2 in PDB entry 1uj0, assembly 1, front view.
Signal transducing adapter molecule 2 in PDB entry 1uj0, assembly 1, side view.
Signal transducing adapter molecule 2 in PDB entry 1uj0, assembly 1, top view.
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Ubiquitin carboxyl-terminal hydrolase 8
Chain: B
Length: 11 amino acids
Theoretical weight: 1.28 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q80U87 (Residues: 699-709; Coverage: 1%)
Gene names: Kiaa0055, Ubpy, Usp8
Ubiquitin carboxyl-terminal hydrolase 8 in PDB entry 1uj0, assembly 1, front view.
Ubiquitin carboxyl-terminal hydrolase 8 in PDB entry 1uj0, assembly 1, side view.
Ubiquitin carboxyl-terminal hydrolase 8 in PDB entry 1uj0, assembly 1, top view.
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