PDBe 1uhl

X-ray diffraction
2.9Å resolution

Crystal structure of the LXRalfa-RXRbeta LBD heterodimer

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Oxysterols receptor LXR-alpha Chain: B
Molecule details ›
Chain: B
Length: 242 amino acids
Theoretical weight: 28.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13133 (Residues: 207-447; Coverage: 54%)
Gene names: LXRA, NR1H3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Retinoic acid receptor RXR-beta Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 26.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28702 (Residues: 298-533; Coverage: 44%)
Gene names: NR2B2, RXRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 10 amino acids
Theoretical weight: 1.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 687-696; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P212121
Unit cell:
a: 67.634Å b: 88.996Å c: 90.795Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.219 0.326
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided