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Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, UTP

Source organism: Homo sapiens
Biochemical function: ribosylnicotinamide kinase activity
Biological process: CTP salvage
Cellular component: cytosol

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EC 2.7.1.48: Uridine/cytidine kinase

Reaction catalysed:
ATP + cytidine = ADP + CMP
Systematic name:
ATP:uridine/cytidine 5'-phosphotransferase
Alternative Name(s):
  • Pyrimidine ribonucleoside kinase
  • Uridine kinase (phosphorylating)
  • Uridine monophosphokinase
  • Uridine phosphokinase
  • Uridine-cytidine kinase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00485
Domain description: Phosphoribulokinase / Uridine kinase family
Occurring in:
  1. Uridine-cytidine kinase 2
The deposited structure of PDB entry 1uei contains 2 copies of Pfam domain PF00485 (Phosphoribulokinase / Uridine kinase family) in Uridine-cytidine kinase 2. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000764
Domain description: Uridine kinase-like
Occurring in:
  1. Uridine-cytidine kinase 2
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Uridine-cytidine kinase 2
IPR006083
Domain description: Phosphoribulokinase/uridine kinase
Occurring in:
  1. Uridine-cytidine kinase 2

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Uridine-cytidine kinase 2
The deposited structure of PDB entry 1uei contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Uridine-cytidine kinase 2. Showing 1 copy in chain B.
SCOP SCOP annotation
52584
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Uridine-cytidine kinase 2
The deposited structure of PDB entry 1uei contains 2 copies of SCOP domain 52584 (Phosphoribulokinase/pantothenate kinase) in Uridine-cytidine kinase 2. Showing 1 copy in chain B.

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