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Crystal structure of rice alpha-galactosidase

Source organism: Oryza sativa
Biochemical function: raffinose alpha-galactosidase activity
Biological process: galactomannan catabolic process
Cellular component: apoplast

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EC 3.2.1.22: Alpha-galactosidase

Reaction catalysed:
Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids
Systematic name:
Alpha-D-galactoside galactohydrolase
Alternative Name(s):
  • Alpha-D-galactosidase
  • Alpha-galactosidase A
  • Alpha-galactoside galactohydrolase
  • Melibiase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF17801
Domain description: Alpha galactosidase C-terminal beta sandwich domain
Occurring in:
  1. Alpha-galactosidase
The deposited structure of PDB entry 1uas contains 1 copy of Pfam domain PF17801 (Alpha galactosidase C-terminal beta sandwich domain) in Alpha-galactosidase. Showing 1 copy in chain A.

PF16499
Domain description: Alpha galactosidase A
Occurring in:
  1. Alpha-galactosidase
The deposited structure of PDB entry 1uas contains 1 copy of Pfam domain PF16499 (Alpha galactosidase A) in Alpha-galactosidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002241
Domain description: Glycoside hydrolase, family 27
Occurring in:
  1. Alpha-galactosidase
IPR041233
Domain description: Alpha galactosidase, C-terminal beta sandwich domain
Occurring in:
  1. Alpha-galactosidase
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. Alpha-galactosidase
IPR000111
Domain description: Glycoside hydrolase family 27/36, conserved site
Occurring in:
  1. Alpha-galactosidase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Alpha-galactosidase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Alpha-galactosidase

Structure domains

CATH CATH domains
2.60.40.1180
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Golgi alpha-mannosidase II
Occurring in:
  1. Alpha-galactosidase
The deposited structure of PDB entry 1uas contains 1 copy of CATH domain 2.60.40.1180 (Immunoglobulin-like) in Alpha-galactosidase. Showing 1 copy in chain A.
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Alpha-galactosidase
The deposited structure of PDB entry 1uas contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in Alpha-galactosidase. Showing 1 copy in chain A.
SCOP SCOP annotations
51012
Class: All beta proteins
Fold: Glycosyl hydrolase domain
Superfamily: Glycosyl hydrolase domain
Occurring in:
  1. Alpha-galactosidase
The deposited structure of PDB entry 1uas contains 1 copy of SCOP domain 51012 (alpha-Amylases, C-terminal beta-sheet domain) in Alpha-galactosidase. Showing 1 copy in chain A.
51446
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: (Trans)glycosidases
Occurring in:
  1. Alpha-galactosidase
The deposited structure of PDB entry 1uas contains 1 copy of SCOP domain 51446 (Amylase, catalytic domain) in Alpha-galactosidase. Showing 1 copy in chain A.

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