PDBe 1uaq

X-ray diffraction
1.6Å resolution

The crystal structure of yeast cytosine deaminase

Released:

Function and Biology Details

Reaction catalysed:
Cytosine + H(2)O = uracil + NH(3). 
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosine deaminase Chains: A, B
Molecule details ›
Chains: A, B
Length: 158 amino acids
Theoretical weight: 17.53 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12178 (Residues: 1-158; Coverage: 100%)
Gene names: FCY1, YP9499.17, YPR062W
Sequence domains: Cytidine and deoxycytidylate deaminase zinc-binding region
Structure domains: Cytidine Deaminase, domain 2

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 47.113Å b: 53.681Å c: 68.076Å
α: 90° β: 105.33° γ: 90°
R-values:
R R work R free
0.178 0.177 0.215
Expression system: Escherichia coli