Function and Biology

STRUCTURE OF UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE

Source organism: Escherichia coli
Biochemical function: transferase activity
Biological process: cell division
Cellular component: cytosol

EC 2.5.1.7: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Reaction catalysed:
Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP- N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.
Systematic name:
Phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase
Alternative Name(s):
  • MurA transferase
  • UDP-N-acetylglucosamine 1-carboxyvinyl-transferase
  • UDP-N-acetylglucosamine enoylpyruvyltransferase
  • Enoylpyruvate transferase
  • Phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase
  • Phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase
  • Phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase
  • Phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase
  • Phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase
  • Pyruvate-UDP-acetylglucosamine transferase
  • Pyruvate-uridine diphospho-N-acetyl-glucosamine transferase
  • Pyruvate-uridine diphospho-N-acetylglucosamine transferase
  • Pyruvic-uridine diphospho-N-acetylglucosaminyltransferase
  • Phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase

Sequence family

CATH Protein family (Pfam)
PF00275
Domain description: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
Occurring in:
  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase
1 copy of Pfam domain PF00275 (EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)) in UDP-N-acetylglucosamine 1-carboxyvinyltransferase in PDB 1uae.

CATH InterPro annotations
IPR001986
Domain description: Enolpyruvate transferase domain
Occurring in:
  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase
IPR005750
Domain description: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Occurring in:
  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase
IPR013792
Domain description: RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
Occurring in:
  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Structure domain

CATH CATH domain
3.65.10.10
Class: Alpha Beta
Architecture: Alpha-beta prism
Topology: UDP-n-acetylglucosamine1-carboxyvinyl-transferase; Chain
Homology: UDP-n-acetylglucosamine1-carboxyvinyl-transferase; Chain
Occurring in:
  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase
2 copies of CATH domain 3.65.10.10 (UDP-n-acetylglucosamine1-carboxyvinyl-transferase; Chain) in UDP-N-acetylglucosamine 1-carboxyvinyltransferase in PDB 1uae.
SCOP SCOP annotation
55209
Class: Alpha and beta proteins (a+b)
Fold: IF3-like
Superfamily: EPT/RTPC-like
Occurring in:
  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase