Function and Biology

Crystal structure of cruzain bound to an alpha-ketoester

Source organism: Trypanosoma cruzi
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

EC 3.4.22.51: Cruzipain

Reaction catalysed:
Broad endopeptidase specificity similar to that of cathepsin L.
Systematic name:
-
Alternative Name(s):
  • Congopain
  • Cruzain
  • Evansain
  • Trypanopain

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Cruzipain
The deposited structure of PDB entry 1u9q contains 1 copy of Pfam domain PF00112 (Papain family cysteine protease) in Cruzipain. Showing 1 copy in chain A [auth X].

InterPro InterPro annotations
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Cruzipain
IPR025661
Domain description: Cysteine peptidase, asparagine active site
Occurring in:
  1. Cruzipain
IPR025660
Domain description: Cysteine peptidase, histidine active site
Occurring in:
  1. Cruzipain
IPR000169
Domain description: Cysteine peptidase, cysteine active site
Occurring in:
  1. Cruzipain
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Cruzipain
IPR039417
Domain description: Papain-like cysteine endopeptidase
Occurring in:
  1. Cruzipain
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Cruzipain

Structure domain

CATH CATH domain
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Cruzipain
The deposited structure of PDB entry 1u9q contains 1 copy of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Cruzipain. Showing 1 copy in chain A [auth X].
SCOP SCOP annotation
54002
Class: Alpha and beta proteins (a+b)
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Occurring in:
  1. Cruzipain
The deposited structure of PDB entry 1u9q contains 1 copy of SCOP domain 54002 (Papain-like) in Cruzipain. Showing 1 copy in chain A [auth X].