PDBe 1u7u

X-ray diffraction
2.4Å resolution

Phosphopantothenoylcysteine synthetase from E. coli

Released:

Function and Biology Details

Reactions catalysed:
N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO(2). 
CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coenzyme A biosynthesis bifunctional protein CoaBC Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 24.83 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0ABQ0 (Residues: 181-406; Coverage: 56%)
Gene names: JW5642, b3639, coaBC, dfp
Sequence domains: DNA / pantothenate metabolism flavoprotein
Structure domains: CoaB-like

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: C2
Unit cell:
a: 52.93Å b: 57.255Å c: 78.756Å
α: 90° β: 108.86° γ: 90°
R-values:
R R work R free
0.236 0.221 0.279
Expression system: Escherichia coli