Function and Biology

NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00018
Domain description: SH3 domain
Occurring in:
  1. Cytoplasmic protein NCK2
1 copy of Pfam domain PF00018 (SH3 domain) in Cytoplasmic protein NCK2 in PDB 1u5s.

PF00412
Domain description: LIM domain
Occurring in:
  1. LIM and senescent cell antigen-like-containing domain protein 1
1 copy of Pfam domain PF00412 (LIM domain) in LIM and senescent cell antigen-like-containing domain protein 1 in PDB 1u5s.

InterPro InterPro annotations
IPR001452
Domain description: SH3 domain
Occurring in:
  1. Cytoplasmic protein NCK2
IPR001781
Domain description: Zinc finger, LIM-type
Occurring in:
  1. LIM and senescent cell antigen-like-containing domain protein 1
IPR017351
Domain description: LIM and senescent cell antigen-like-containing domain protein 1
Occurring in:
  1. LIM and senescent cell antigen-like-containing domain protein 1
IPR036028
Domain description: SH3-like domain superfamily
Occurring in:
  1. Cytoplasmic protein NCK2
IPR035561
Domain description: Nck2, SH3 domain 3
Occurring in:
  1. Cytoplasmic protein NCK2

Structure domains

CATH CATH domains
2.10.110.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Cysteine Rich Protein
Homology: Cysteine Rich Protein
Occurring in:
  1. LIM and senescent cell antigen-like-containing domain protein 1
1 copy of CATH domain 2.10.110.10 (Cysteine Rich Protein) in LIM and senescent cell antigen-like-containing domain protein 1 in PDB 1u5s.
2.30.30.40
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: SH3 Domains
Occurring in:
  1. Cytoplasmic protein NCK2
1 copy of CATH domain 2.30.30.40 (SH3 type barrels.) in Cytoplasmic protein NCK2 in PDB 1u5s.
SCOP SCOP annotations
57736
Class: Small proteins
Fold: Glucocorticoid receptor-like (DNA-binding domain)
Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
Occurring in:
  1. LIM and senescent cell antigen-like-containing domain protein 1
2 copies of SCOP domain 57736 (LIM domain) in LIM and senescent cell antigen-like-containing domain protein 1 in PDB 1u5s.
50045
Class: All beta proteins
Fold: SH3-like barrel
Superfamily: SH3-domain
Occurring in:
  1. Cytoplasmic protein NCK2
1 copy of SCOP domain 50045 (SH3-domain) in Cytoplasmic protein NCK2 in PDB 1u5s.