PDBe 1u59

X-ray diffraction
2.3Å resolution

Crystal Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ZAP-70 Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 33.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43403 (Residues: 327-606; Coverage: 45%)
Gene names: SRK, ZAP70
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 43.056Å b: 57.064Å c: 125.133Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.271
Expression system: Spodoptera frugiperda